Matthew C. Murphy1, John Huston, III1, Clifford R. Jack, Jr. 1, Kevin J. Glaser1, Armando Manduca1, Joel P. Felmlee1, Richard L. Ehman1
1Department of Radiology,
MRE is a technique for noninvasively measuring tissue stiffness. The purpose of this work was to assess reproducibility of a 3D MRE exam of the brain in 10 healthy volunteers, and to use the 3D brain MRE exam to study the effects of Alzheimers disease (AD) in 7 subjects with probable AD, 14 age- and gender-matched PIB- controls and 7 age- and gender-matched PIB+ controls. MRE detected a significant decrease in brain stiffness in subjects with AD compared to both control groups. This decrease in stiffness likely reflects a loss of normal cytoarchitecture of the brain parenchyma due to AD.