Jochen Keupp1, Christof Baltes2, Paul R. Harvey2, Johan van den Brink2
Amide proton transfer (APT)-MRI is expected to have clinical applications in oncology (enriched protein levels in tumors) and neurology (ischemic acidosis in stroke). While successful APT applications have been shown in the human brain, sensitivity was typically limited due to RF amplifier hardware specifications of the clinical systems. Herein, a novel scheme for prolonged RF saturation (≥3 sec) is demonstrated, which is based on alternated parallel RF transmission into the body-coil and bears the potential for a twofold sensitivity gain. Sequence variants are assessed for optimal sensitivity, and feasibility of APT mapping in the human head is demonstrated.