Catherine D. G. Hines1, Ian Rowland2, Calista Roen1, Diego Hernando1, Debra Horng2, Huanzhou Yu3, Jean Brittain4, Scott B. Reeder1
1Radiology, University of Wisconsin-Madison, Madison, WI, USA; 2Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; 3Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA; 4Global Applied Science Laboratory, GE Healthcare, Waukesha, WI, USA
Iron overload often occurs concurrently in chronic liver disease patients, confounding accurate liver fat quantification. Recent work has demonstrated the importance of T2* corrections for quantifying liver fat, using quantitative MRI imaging and spectroscopic methods. Consequently, this work validates the requirement for T2* corrections for fat quantification in an animal model of steatosis with increasing iron overload. In vivo results show this method is robust to increasing iron over a range of fat-fractions, T2* correction is necessary in the presence and absence of iron, and that MRI fat quantification is predictive of amount of stored triglycerides.