Hanzhang Lu1, Feng Xu1, Ksenija Grgac2,3, Peiying Liu1, Qin Qin2,3, Peter van Zijl2,3
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Radiology, Johns Hopkins University, Baltimore, MD, USA; 3F.M. Kirby Center, Kennedy Krieger Institute, Baltimore, MD, USA
Recently, a T2-Relaxation-Under-Spin-Tagging (TRUST) MRI technique was developed to quantitatively estimate blood oxygenation (Y) via the measurement of pure blood T2. However, a human validation study has not been conducted. Here we used in vitro blood experiments to determine a 3-dimentional calibration plot in which blood T2 is a function of both Y and Hct. We further showed that, during hypoxia, Ya measured with PulsOx was 84.03.6% (N=7), while Ya derived from TRUST blood T2 and in vitro calibration plot was 83.73.6%. Furthermore, a significant correlation was observed between these two measures across subjects (P=0.05).