Feng Zhang1, Jiakai Li1, Yanfeng
Meng1, Jihong Sun1, Stephanie
1Image-Guided Bio-Molecular Intervention Section, Department of Radiology, University of Washington School of Medicine, Seattle, WA, United States
This study was to develop a new technique of intrabiliary MRI-guided local agent delivery. We first confirmed the capability of motexafin gadolinium(MGd) entering cholangiocarcinoma cells. Then, we established surgical protocol for intrabiliary balloon-mediated MGd delivery into pig common bile duct (CBD) walls ex vivo. We finally validated the feasibility of using MR to monitor, in vivo, intrabiliary delivery of MGd into the pig CBD wall of a pig, which was confirmed by subsequent MRI-histology correlation. This new technique may open new revenues for MR-guided intrabiliary local delivery of therapeutics, such as genes and drugs, to treat malignant pancreatobiliary diseases.