Andrew James Gilman1, Susan Moyher
Noworolski1, Mamak Eatesam1, Jennifer Lynne Dodge1,
Raphael Brendan Merriman2, Aliya Qayyum1
1Radiology & Biomedical
Imaging, University of California, San Francisco, San Francisco, CA, United
States; 2Division of Gastroenterology, California Pacific Medical
Center, San Francisco, CA, United States
The relationship between liver ADC and steatosis was evaluated for high (125, 500), low (0, 125), and conventional (0, 500) b-value DWI at 3T in 6 healthy volunteers and 12 patients with NAFLD or HCV. Subjects with steatosis grade 1 or 2 (n=5) had significantly lower high b-value ADC compared to those with grade 0 (n=13) for both large (0.88 versus 1.09, p<0.04) and small (0.82 versus 1.12, p<0.02) ROIs. The effect of steatosis on liver ADC should be taken into account when using DWI to discriminate between features of diffuse liver disease.