Thomas L. Chenevert1, Craig J. Galbn1, Frank J. Londy1, Charles R. Meyer1, Timothy D. Johnson2, Alnawaz Rehemtulla3, Brian D. Ross1
1Radiology - MRI, University of Michigan, Ann Arbor, MI, United States; 2Biostatistics, University of Michigan, Ann Arbor, MI, United States; 3Radiation Oncology, University of Michigan, Ann Arbor, MI, United States
Prerequisites for use of ADC, as well as any image-based biomarker in multi-center trials is standardization of data acquisition/analysis, and certification of sites/systems via quantitative measurements on known test objects. The objective of this study is to assess reproducibility of ADC measurements performed at multiple sites on various clinical platforms using icewater as a simple universal temperature-controlled diffusing medium. In this study system outlier(s) were identified, and 3-5% reproducibility in diffusion coefficient measurement exclusive of outliers was demonstrated. Systematic spatial-dependent error was also demonstrated with its source under investigation.