Jing Qi1, Mithat Gnen2, Jinru
Shia3,
1Medical Physics, Memorial
Sloan-Kettering Cancer Center, New York, NY, United States; 2Epidemiology-Biostatistics,
Memorial Sloan-Kettering Cancer Center; 3Pathology, Memorial
Sloan-Kettering Cancer Center; 4Radiology, Columbia University
Medical School; 5Medicine,
Memorial Sloan-Kettering Cancer Center; 6Surgery, Memorial
Sloan-Kettering Cancer Center
To assess the reproducibility of hepatocellular triglyceride content measurements on a 1.5T scanner using 1H MRS during a single breath-hold, 16 heathy adults were studied twice with a 2 week interval. The intra- and inter- examination coefficients of variance were 6% and 15% respectively. To evaluate the accuracy of 1H MRS in quantitation of HTGC, fat/(fat+water) (FFW) from 16 colorectal cancer patients was correlated with liver histology. A positive correlation (r = 0.78, P < 0.001) was observed between FFW and histology steatosis grade. A FFW cutoff value of 0.025 results in 86% sensitivity and 89% specificity for detection of clinically relevant steatosis.