Arunima Pola1, Sandra Tan2,
Terry Yew Shze Keong3, Zhihong Zhou2, Mika Murabayashi4,
Yoshihide Nakano4, Naoki Furuyama4, Nicholas Hird4,
Sendhil Sambashivam Velan3
1Laboratory of Molecular
Imaging, Singapore Bioimaging Consortium, , Singapore, Singapore; 2Takeda
Singapore Pte Ltd, Singapore; 3Laboratory of Molecular Imaging,
Singapore Bioimaging Consortium, Singapore, Singapore; 4Takeda Pharmaceutical
Company Ltd, Japan
Obesity is a medical condition in which excess body fat accumulates in areas such as abdomen, liver and skeletal muscle. In this study, experimental rodent models of obesity were used to investigate fat accumulation in these organs by longitudinal in vivo MRS/MRI measurements. Fat estimation in the abdomen was based on axial image segmentation. Spectral analysis by LCModel was used for fat calculation in liver and skeletal muscle. All our measurements are correlated with body weight, food intake and blood chemistry. The results demonstrate that MRI/MRS approach can be used to evaluate the potential of novel drugs in rodent models of obesity and diabetes.