John Nouls1,2, Zackary I. Cleveland1,2, Matthew S. Freeman3, Harald E. Moeller4, Laurence W. Hedlund1,2, Bastiaan Driehuys1,2
1Department of Radiology, Duke University, Durham, NC, United States; 2Center for In Vivo Microscopy, Duke University, Durham, NC, United States; 3Medical Physics, Duke University; 4Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
We demonstrate that acquiring isotropic, 3D images of the 129<\sup>Xe distribution in the rat brain is feasible. The images are obtained by simple inhalation delivery within 5 min. However, the intensity in these images display significant heterogeneity. The presence of this heterogeneity, which was not reported in earlier 2D imaging studies, suggests that the distribution of <sup>129<\sup>Xe in the brain is sensitive to a variety of physiologically and anatomically important factors including perfusion, tissue type, and tissue chemistry.