Magdalena Zurek1, Laurent Boyer2, Philippe Caramelle2, Jorge Boczkowski2, Yannick Crmillieux1
1University of Lyon,
Tissue density losses and microstructural changes of the lung parenchyma present in emphysema disease can affect both, the MR image intensity and T2* values. Using an ultra-short echo-time (UTE) sequence, signal intensity and T2* changes were track in emphysema disease progression along an 8-weeks longitudinal study in elastase-challenged mice. The MR findings were confirmed by histology. The MR results are in good agreement with published CT observations and with predictions from a physical model. This technique is readily suitable for routine drug testing in experimental MR lung research of emphysema and can be transferred to human studies.