Mirabelle Sajisevi1,2, David A. Bellnier3, Nestor Rigual2, Mukund Seshadri1,4
1Preclinical Imaging Facility, Roswell Park Cancer Institute, Buffalo, NY, United States; 2Head & Neck Surgery, Roswell Park Cancer Institute, Buffalo, NY, United States; 3Cell Stress Biology, Roswell Park Cancer Institute; 4Pharmacology & Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, United States
The biological response of tumors to photodynamic therapy (PDT) is complex and involves a combination of cell kill, vascular damage, and induction of immune/inflammatory responses, all of which result in varying changes in contrast on MR images. In this study, we examined the utility of MRI in monitoring tissue response to PDT in an invasive, intramuscular model of squamous cell carcinoma. Our results demonstrate the potential value of MRI as a tool to monitor PDT-induced tissue damage in vivo.