Jeon-Hor Chen1,2, Siwa Chan3, Daniel H-E Chang1, Muqing Lin1, Orhan Nalcioglu1, Min-Ying L. Su1
1Center for Functional Onco-Imaging & Department of Radiological Science, University of California Irvine, Irvine, CA, United States; 2Department of Radiology, China Medical University Hospital, Taichung, Taiwan; 3Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan
The variation of breast density measured from 4 different scanners (GE 1.5T, GE 3T, Siemens 1.5T, Philips 3T) was investigated. The breast volume, fibroglandular tissue volume, and the percent density were measured using computer algorithms. The image qualities of all 4 scanners are superb for density segmentation. Philips 3T has the highest SNR, and Siemens 1.5T has the best tissue contrast. The coefficient of variation is 4.0% for BV, 6.2% for FV; and 6.0% for PD. The results suggest that with a careful standardization in acquisition and analysis, density parameters obtained from multiple centers may be used for combined analysis.