Savannah C. Partridge1, Habib Rahbar1,
Revathi Murthy2, Xiaoyu Chai3, Brenda Kurland3,
1Radiology, University of Washington, Seattle, WA, United States; 2Bioengineering, University of Washington, Seattle, WA, United States; 3Clinical Statistics, Fred Hutchinson Cancer Research Center, Seattle, WA, United States
In this study, we investigated the correlation between ADC and DCE kinetic characteristics of 100 breast lesions and evaluated the relative diagnostic value of each quantitative measure alone and in combination. We found that lower ADC values (higher cellularity) were associated with more suspicious kinetics and that both DWI and DCE parameters significantly discriminated between benign and malignant lesions. A multivariate model incorporating ADC and worst kinetic curve type provided the greatest discriminative ability, suggesting that DWI provides distinct and complementary information to DCE for characterizing breast lesions.