Fang Liu1,2, Anat Kornecki3, Olga Shmuilovich3, Neil Gelman1,2
1Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 2Imaging Division, Lawson Health Research Institute, London, Ontario, Canada; 3Department of Diagnostic Imaging, St. Joseph's Health Center, London, Ontario, Canada
Various empirical parameters have been employed for quantitative analysis of signal enhancement curves in dynamic contrast enhanced-MRI. Among them, the time-to-peak has shown promise as a diagnostic indicator. In this study, a measure to be referred to as the time-to-peak hot spot volume was analyzed and optimized for differentiating benign versus malignant breast lesion. An investigation of the relation of hot spot volume to the lesion volume was also investigated. Our results suggest that quantitative analysis of the time-to-peak hot spot volume can be optimized for diagnostic performance providing indicators for differentiating benign versus malignant breast lesions.