Apparent Diffusion Coefficient Values During Magnetic Resonance -Guided Biopsy of the Prostate: Correlation with Histological Results

Martijn Gerjan Schouten¹, N. A. Nagel¹, Thomas Hambrock¹, Caroline M. Hoeks¹, Joyce Gerda Riek Bomers¹, Pieter C. Vos¹, Jurgen J. Futterer¹

Purpose of this study was to investigate the correlation between diffusion weighted imaging and histopathology obtained during the same MRI guided biopsy session. Apparent diffusion coefficient (ADC) maps were merged with images obtained after needle insertion to determine the ADC-value of the biopsy specimen. Two-tailed t-tests were performed to determine differences between groups. Significant differences were considered at p <.05. The mean ADC-values of men with malignant and non-malignant prostate cancer were significant different. Significant differences were seen between prostatitis and cancer and between healthy specimen and prostatitis. No significant difference was seen between high- and low- grade cancer.