Nadine El Tannir El Tayara1,2, Nidhal Ben Achour1,2, Christine Walczak1,2, Fariba Nemati3, Joel Mispelter1,2, Didier Decaudin3, Julien Vautier1,2, Andreas Volk1,2
1Research Center, Institut Curie, Orsay, France; 2U759 INSERM, Orsay, France; 3Translational Research Department, Institut Curie, Paris, France
The purpose of this work was to evaluate a new quantitative DCE-MRI technique combining 3D tumor imaging with interleaved high time resolution 2D heart imaging (AIF) in a context of treatment follow-up. We investigated its ability to assess early change of microvascular parameters under anti-angiogenic therapy (Sunitinib) and showed a histograms Ktrans distribution shift towards lower values at day 4 after treatment initiation. Significant decrease in Ktrans median and mode values was observed, as well as tumor growth inhibition over the 11 days treatment period. Results were compatible with a predictive value of these Ktrans parameters for anti-angiogenic treatment response.