Comparison of DCE-MRI & Dual Echo DSC-MRI Derived Measures of Ktrans & ve

Christopher Chad Quarles¹, John Christopher Gore¹, Thomas Edison Yankeelov¹

We have previously demonstrated that dual-echo DSC-MRI can be used to separate and quantify T₁ and T₂* based contrast agent leakage effects and, when combined with a pre-contrast T₁ map, quantify the DCE-MRI parameters, K^trans and v_e. To further verify this approach we now compare DSC-MRI and DCE-MRI derived K^trans and v_e values in two brain tumor models with dissimilar perfusion characteristics and contrast agent dynamics. The DSC-MRI and DCE-MRI parameters were highly correlated and in good agreement as no significant differences were found in either of the tumor models.