Chamith S. Rajapakse1, Yusuf A. Bhagat1, Mary B. Leonard2, Jeremy F. Magland1, James H. Love1, Wenli Sun1, Felix W. Wehrli1
1University of Pennsylvania School of Medicine, Philadelphia, PA, United States; 2The Children's Hospital of Philadelphia, Philadelphia, PA, United States
Ordinarily, when generating micro-finite-element (μFE) models on the basis of High-resolution MRI (μMRI), bone tissue is assumed to have a constant modulus because μMRI-based in-vivo measures of bone mineralization are not yet available. As a consequence, μMRI-based μFE analysis is not sensitive to changes in bone-mineral density (BMD) observed in patient populations such as those who undergo renal transplantation (RTxp). Here, we demonstrate the increased sensitivity achieved when using μMRI-based μFE models of distal tibia with subject-specific tissue modulus which incorporate peripheral quantitative computed tomography (pQCT)-derived BMD measures compared to when a constant modulus is assumed in RTxp recipients.