Andrew Louis Wentland1,2, Oliver Wieben1, Kevin M. Johnson1, Chris J. Francois2, Thomas M. Grist2, Alex Frydrychowicz2
Pulse wave velocity (PWV) is a useful biomarker of vascular stiffness. We investigated the use of a radially undersampled 4D PC MRI acquisition with high temporal resolution for computing PWV; PWV was computed by analyzing flow waveforms in 7-8 planes along the thoracic aorta in five volunteers. These PWV measurements were compared to PWV measurements derived from four 2D PC slices. PWV was computed with four methods: time-to-upstroke, time-to-peak (TTP), time-to-foot (TTF), and cross-correlation (XCorr). 2D TTP, TTF, and XCorr and 4D TTF produced non-physiologic results. 4D results were less variable than the 2D results.