Terrence Jao1, Zungho Zun2,
Padmini Varadarajan3, Ramdas Pai3,
1Keck School of Medicine, University of Southern California, Los Angeles, CA, United States; 2Electrical Engineering, University of Southern California, Los Angeles, CA, United States; 3Division of Cardiology, Loma Linda University Medical Center, Loma Linda, CA, United States
Arterial spin labeled MRI is an emerging approach for measuring myocardial perfusion and perfusion reserve in humans. The technique requires acquisition and registration of multiple tagged and control images and suffers from low signal-to-noise ratio. In this work, we address these two challenges by spatially aligning and spatio-temporally filtering myocardial ASL data in a polar coordinate frame. We demonstrate that this approach facilitates assessment of regional perfusion and perfusion reserve in patients.