Eissa Aguor1, Cees W. A. van De Kolk1,
Marcel G. J. Nederhoff1, Pieter A. F. M. Doevendans1,
Gerard Pasterkamp1, Gustav J. Strijkers2, Fatih Arslan1,
Cees J. A. van Echteld1
1Department of Cardiology,
University Medical Center Utrecht, Utrecht, Netherlands; 2Biomedical
NMR, Department of Biomedical Engineering, Eindhoven University of
Technology, Eindhoven, Netherlands
Assessment of myocardial viability is essential for diagnosis and treatment of patients with coronary artery disease. DCE MRI is the gold standard for chronic infarct size but may be less accurate in acute infarcts due to edema. Instead, we have explored 23Na CSI in an isolated heart model of edema with different perfusion pressures, independently characterized by 31P MRS. A perfusion pressure of 140 mmHg resulted in an increase in cross sectional area of the heart and a larger distribution volume for PPA, Nae and Gd. Unexpectedly, images of Nai also showed an small increase in signal intensity.