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Abstract #1381

Cerebral Glucose Uptake in Humans at Hypoglycemic Plasma Levels Follows Reversible Michaelis-Menten Kinetics

Kim C. C. van De Ven1, Marinette van Der Graaf1,2, Bastiaan E. de Galan3, Cees J. J. Tack3, Arend Heerschap1

1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Paediatrics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 3General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands


In this study human cerebral glucose content was determined during moderate hypoglycemia (~3 mM), in order to assess values of reversible MM kinetic parameters for glucose transport and compare this with previous data on glucose transport into the brain assessed during eu- and hyperglycemia. We found MM parameters Tmax/CMRglc = 2.93 and Kt = 3.27 mM, which is in agreement with previously published data in humans, and it is also in agreement with findings in rats under hypoglycemic conditions. We conclude that the reversible MM model is also valid at moderate hypoglycemic values.