Changho Choi1, Sandeep Ganji1,
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Internal Medicine & Neuro-oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States
Two-dimensional (2D) J-resolved spectroscopy may provide improved resolution for J-coupled resonances compared to conventional 1D data acquisitions. Single-voxel localized PRESS (point-resolved spectroscopy) data were acquired at 32 echo times from the tumor mass and contralateral normal-brain regions of three glimablastoma patients. The 2D NMR data were analyzed with spectral fitting (LCModel), using basis sets prepared with numerical calculation of model spectra that incorporated the actual parameters identical to those used in the data acquisition.