Mariska Petra Luttje1, Michael Wyss1,2, Niklaus Zlch1,2, Alexander Fuchs1, Richard A. E. Edden3,4, Susanne Heinzer5, Peter Bsiger1, Anke Henning1
1Institute for Biomedical Engineering, University & ETH Zurich, Zurich, Switzerland; 2Contributed equally; 3Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 5Philips AG, Zurich, Switzerland
SV PRESS, MEGA-PRESS and localized 2D JPRESS are compared to investigate their ability of quantifying GABA, Glu, Gln and GSH accurately. ERETIC has been applied as a reliable reference. Next to this, for all sequences the metabolite ratios with the internal water reference were calculated. JPRESS shows to be the best method for simultaneous quantification of the selected metabolites, while MEGA-PRESS GABA-editing proofs to be a faster and reliable method for studies that target mainly GABA. The metabolite/ERETIC ratio shows to be a more stable and hence reliable quantification method compared to the metabolite/water reference ratio for all tested sequences.