Alexander Fuchs1, Anke Henning1, Mariska P. Luttje2, Maarten J. Versluis3, Roland Kreis4, Peter Boesiger2
1Institute for Biomedical Engineering , University & ETH Zurich, Zurich, Switzerland; 2Institute for Biomedical Engineering, University & ETH Zurich, Zurich, Switzerland; 3Dept. of Radiology, Leiden University Medical Center, Leiden, Netherlands; 4Dept. of Clinical Research, University of Bern, Bern, Switzerland
Beside the commonly investigated resonances between water and lipids there is also a growing interest to detect and quantify metabolite signals on the downfield part of the spectrum (4.7-8ppm). However, measuring up- and downfield resonances in the same spatial region simultaneously involves a few problems. In this work, it is shown that inner volume saturation can be used to control the rather large chemical shift displacement artifact between 1.33 and 8ppm while SPECIAL localization offers short echo times and sufficient SNR to detect and quantify also the downfield resonance at 7T.