Ulrike Dydak1,2, Jun Sai Xu1,2, Malgorzata Marjanska3, Stefan Posse4,5
1School of Health Sciences, Purdue University, West Lafayette, IN, United States; 2Department of Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States; 3Center for Magnetic resonance Research & Department of Radiology, University of Minnesota, Minneapolis, MN, United States; 4Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, United States; 5Department of Electrical & Computer Engineering, University of New Mexico, Albuquerque, NM, United States
3D GABA mapping of the human brain is presented by combining the MEGA-editing scheme with the fast PEPSI spectroscopic imaging approach. In vivo data shows high data quality across several 1.5cm-thick brain slices, including coverage of cortical areas, allowing for reliable LCModel fitting of the GABA signal. 3D MEGA-PEPSI enables the acquisition of 32x32x8 difference spectra within only 17 min of scan time with a nominal voxel size of below 4ml, yielding GABA-edited spectra with similar SNR as achieved in single voxel scans and allowing for large anatomical coverage.