Deirdre Maria McGrath1, Warren D. Foltz1, Kristy K. Brock1,2
1Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada; 2Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
Validation of medical imaging for disease detection and localization is achieved by correlation with the gold-standard of histopathology. For accurate 3D biomechanical registration of the histopathology volume with the imaging volume, the effect of pathology fixation on biomechanical ex vivo tissue properties must be incorporated. A quasi-static MRE method at 7 tesla was applied to measure the progressive effects of formalin fixation in preclinical and clinical prostate tissue, and increases in Youngs modulus with fixation were correlated with decreases in T1, T2 and ADC. This will allow the formulation of predictive models of material property changes using standard MRI parameters.