Ashish K. Jindal1, Lloyd Lumata1, Yixun Xing2, Matthew E. Merritt1, Piyu Zhao2, Craig R. Malloy1, A. Dean Sherry1,2, Zoltan Kovacs1
1Advanced Imaging, UT Southwestern Medical Center, Dallas, TX, United States; 2Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States
The extremely long T1 (up to 10 minutes) and T 2 (up to 15 seconds) of 89Y, coupled with 100% natural abundance, spin, and narrow linewidth, make it an attractive nucleus for hyperpolarized in vivo imaging. Here we present accurate T1 measurements of hyperpolarized 89Y DTPA, DOTA, EDTA, and deuterated EDTA complexes. Results suggest that substitution of low-gamma nuclei on the ligand backbone as opposed to that of the solvent most effectively increase the 89Y T1. These results are encouraging for in vivo applications as the presence of bound water may not dramatically affect the T1.