Chi Wah Wong1, Valur Olafsson1, Omer Tal1, Anna Leigh Rack-Gomer1, Thomas T. Liu1
1Center for Functional MRI, University of California San Diego, La Jolla, CA, United States
Recent work in monkeys suggests that the BOLD global signal typically removed as a nuisance term in resting-state studies may have a neural origin. In this study we used simultaneous EEG-fMRI in humans to show that the global signal has a significant component of neuroelectrical origin. In addition, we show that the detection of the anti-correlated relation between the default mode network and the task positive network seems to depend on the removal of this neuroelectrical global signal component.