An Vo1, Aziz M. Ulug1,2,
1The Feinstein Institute for Medical Research, Manhasset, NY, United States; 2Department of Radiology, Albert Einstein School of Medicine, Bronx, NY, United States; 3National Jewish Health, Denver, CO, United States; 4University of Colorado Medical Center, Denver, CO, United States; 5Hospital for Special Surgery, New York, United States; 6Weill Medical College of Cornell University, New York, United States
Most patients with systemic lupus erythematosus (SLE) have cognitive dysfunction suggesting but clinically important central nervous system involvement. Antiphospholipid syndrome is another autoimmune disorder defined as the presence of arterial or venous thromboses and/or pregnancy morbidity with persistent antiphospholipid antibodies (APL). Diffusion tensor imaging (DTI) and fMRI has been used to study the SLE and APL patients. The purpose of this study is to use both fMRI and DTI features to automatically classify SLEs, APLs and normal controls.