Jochen Keupp1, Anne H. Schmieder2, Todd A. Williams2, J. S. Allen2, Samuel A. Wickline2, Gregory M. Lanza2, Shelton D. Caruthers2
1Philips Research Europe,
Molecular imaging of integrin-targeted theranostic nanoparticles (NP) may offer profound impact on anti-angiogenic therapy. Previously, the value of ανβ3-targeted nanoparticles (NP) with large payloads of Gd has been shown. This work presents a novel 19F pulse sequence to image clinically-relevant perfluoro-octyl-bromide (PFOB) NP without Gd. Using 19F/1H radial 3D balanced UTE-SSFP sequence, angiogenesis is imaged in a rabbit Vx2 cancer model comparing ανβ3-targeted PFOB-NP with and without Gd. The new sequence is shown to allow robust, sensitive in vivo visualization of cancer-related neovasculature despite the complex resonant peak structure and the extended T1-relaxation time of Gd-free NP.