Peter Adalbert Jarzyna1, Lisette Helene Deddens2, Benjamin H Kann1, Sarayu Ramachandran1, Claudia Calcagno1, Wei Chen1, Anita Gianella1, Rick M. Dijkhuizen2, Arjan W. Griffioen3, Zahi Adel Fayad1, Willem J. M. Mulder1
1Translational & Molecular Imaging Institute, Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands
We developed an angiogenesis specific nanoemulsion platform for the noninvasive assessment of tumor angiogenesis and phenotyping with MRI and optical imaging. This agent was applied to two different nude mice tumor models with established differences in microvessel density (MVD) and angiogenic activity. We demonstrate in this study that after i.v. administration of our nanoparticles we could clearly distinguish the two tumor phenotypes. Differences in tumor biodistribution were shown by MRI, while differences in time resolved tumor accumulation were quantitatively assessed with near infrared fluorescence imaging.