Gavin D. Kenny1,2, Katharina Welser3,
Frederick Campbell3, Aristides D. Tagalakis1, Helen C.
Hailes3, Alethea B. Tabor4, Mark F. Lythgoe2,
Stephen L. Hart1
1Molecular Immunology Unit
ICH, University College London, London, United Kingdom; 2UCL
Centre for Advanced Biomedical Imaging, Division of Medicine & Institute
of Child Health, University College London, London, United Kingdom; 3Department
of Chemistry, University College London, London, United Kingdom; 4Department
of Chemistry, UCL, London, United Kingdom
Nanoparticles that not only mediate functional delivery of therapeutic payload, but also allow monitoring of delivery by MRI are of great interest. Here we describe liposome nanoparticles incorporating a Gd labelled peptide, that act as 'switchable' MR contrast agents, in that upon delivery of the DNA payload inside the cell the signal is enhanced.