Mechanical Release from Paramagnetic Liposomes Triggered by Low Frequency Ultrasound

Enzo Terreno¹, Pierangela Giustetto¹, Daniela Delli Castelli¹, Cinzia Boffa¹, Davide Durando¹, Silvio Aime¹

The mechanical (i.e. non-thermic) release of the liposomal content (MRI agent and/or drug) by using pulsed low-frequency low-intense ultrasound is strongly affected by small changes in the bilayer composition, payload of imaging probe (or drug), size and shape of the nanovesicles. This finding offers the opportunity to selectively trigger the release of imaging reporters, as well as drugs, from a mixture of different nanocarriers, thus opening new therapeutic schemes to improve the overall efficacy of a pharmacological treatment.