Nigel Paul Davies1, Maryam Kalantari Saghafi2, Xiaoyan Pan3, Theodoros N. Arvanitis4, Andrew C. Peet3
1Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; 2School of Physics & Astronomy, University of Birmingham, Birmingham, United Kingdom; 3Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; 4Department of Electrical, Electronic & Computer Engineering, University of Birmingham, Birmingham, United Kingdom
In-vivo 1H MRS can be used as a probe of temperature through its observed linear relationship with water chemical shift. However, such measurements are potentially subject to contributions from fast exchange effects that are dependent on factors such as macromolecular content and microstructure. Few if any studies have addressed the impact of these effects on MRS temperature calibrations. In this study, tissue-like phantoms have been constructed and used to test the effects of macromolecular concentration and dynamics on temperature measurements using 1H MRS, showing a significant linear relationship between the temperature calibrations and the agarose concentration.