Anoop Ramgolam1, Raphal Sablong1, Sandrine Bouvard2, Herv Saint-Jalmes3, Olivier Beuf1
1CREATIS-LRMN, CNRS UMR 5220; Inserm U1044; INSA-Lyon; Universit Lyon 1, Lyon, Rhone-Alpes, France; 2TIGER/IDEE, Neuroscience Research Center, Lyon, Rhone-Alpes, France; 3LTSI, Inserm U642, University Rennes1; Dpartement dImagerie, centre Eugne Marquis, Rennes, Ille et Vilaine, France
Currently only 40% of colorectal cancers are detected during early stages. Flat adenomas (colorectal cancer precursors) which develop just underneath the colonic mucosa, inducing subtle morphological alteration partly explain the low sensitivity of White Light Endoscopy at early stages. We have designed a prototype of a bimodal endoluminal probe capable of simultaneously extracting morphological and biochemical data through high spatial resolution MRI and optical spectroscopy (autofluorescence; diffuse reflectance) respectively. We hereby present the designing process along with the promising preliminary in vivo results allowing mucosa-submucosa complex differentiation correlated to optical data obtained on a rabbit via this novel MRI-optics technique.