In-Tsang Lin1,2, Bing-Hsuan Lei2,3, Hong -Chang Yang4, Jyh-Horng Chen1,2
1Graduate Institute of Biomedical Electronics & Bioinformatics, National Taiwan University, Taipei, 106, Taiwan; 2Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, 106, Taiwan; 3Department of Electrical Engineering, National Taiwan University, Taipei, 106, Taiwan, Taipei, 106, Taiwan; 4Department of Physics, National Taiwan University, Taipei 106, Taiwan
MRI provides useful method for revealing brain structure. Neuroanatomical differences between strains have been studied at the histologic level. However, the scanning time in 3 T MRI needs more than one hour to obtain the enough resolution to reveal neuroanatomical differences between strains. High-temperature superconducting (HTS) radio-frequency (RF) coil has been proposed as a promising tool in the investigation of the tissue microscopy with high resolution due to its low-resistance characteristic for the MR probe design. Our method to reduce the scanning time is using a 40 mm in diameter Bi2Sr2Ca2Cu3Ox (Bi-2223) HTS RF surface coil. In the present study, we succeed to apply HTS RF surface coil to evaluate the brain structural differences between C57BL/6J and 129S1/SvImJ mouse.