David E. Crane1, Bradley J. MacIntos1,2, Ediri Sideso3, James Kennedy3, Ashok Handa4, Manus J. Donahue5, Peter Jezzard5
1Heart & Stroke Foundation Centre for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; 4Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom; 5Clinical Neurology, FMRIB Centre, University of Oxford, Oxford, United Kingdom
A method of calculating quantitative DSC, thereby permitting longitudinal comparison, is demonstrated and applied to patients undergoing carotid endarterectomy surgery. Quantification was performed with the bookend technique, where T1-weighted steady-state measurement of CBV is used to scale DSC-derived absolute CBF values. Subcortical grey matter CBF results agreed with reported values and age trends. Comparison of pre vs. post surgery showed low inter-session variability and significant surgery effects. Thus, the DSC-bookend approach may be useful in characterizing the interaction between hemodynamics and CEA effects thereby helping to identify patients most likely to benefit from surgery.