Atle Bjornerud1,2, Kim Mouridsen3, Kyrre Eeg Emblem4,5
Oslo Univeristy Hospital, Oslo, Norway; 2Dept. of Physics, Univ.
of Oslo, Oslo, Norway; 3Center for Functionally Integrative Neuroscience,
Aarhus University Hospital, Denmark; 4A. A.
We present a method for improved reproducibility of DSC-MRI based perfusion measurements through the generation of a global patient specific tissue residue function obtained at a single time-point using an automatically generated AIF. The global scan-specific tissue response is then combined with the global residue function and the initial AIF to reconstruct a scan-specific AIF used to derive perfusion parameters at each time-point. The method was tested in the analysis of unaffected brain tissue in glioma patients undergoing multiple longitudinal scans and was found to significantly improve reproducibility of perfusion measurements compared to using scan-specific AIFs.