John B. Colby1,2, Lindsay Soderberg1, Catherine Lebel1, Ivo D. Dinov1,3, Paul M. Thompson1,2, Elizabeth R. Sowell1
1Department of Neurology,
Despite the large amount of within-tract variability in diffusion imaging indices like FA, the vast majority of neuroscience applications still utilize a traditional tract-averaged approach for their deterministic tractography analyses. Here, we lay out a straightforward workflow for conducting one type of within-tract analysis that attains an economical balance between accessibility and improved modeling ability. We then demonstrate the advantages of this approach over traditional tract-averaged methods by looking at both within-subject and between-group examples.