Si-Wa Chan1, Yi-Jui Liu2,3,
Dah-Cherng Yeh4, Jeon-Hor Chen5, Fang-Yi Lee6,
Huei-Jen Hsueh4, Kuo-Fang Shao7, Hsiao-Wei Peng1
1Department of Radiology,
Taichung Veterans General Hospital, Taichung, Taiwan, Taiwan; 2Department
of Automatic Control Engineering, Feng-Chia University, Taichung, Taiwan,
Taiwan; 3Master's Program in Biomedical Informatics &
Biomedical Engineering, Feng-Chia University, Taichung, Taiwan, Taiwan; 4Division of
General Surgery, Taichung Veterans General Hospital, Taichung, Taiwan,
Taiwan; 5Center for Functional Onco Imaging, University of
California, Irvine, CA, United States; 6Department of Physicain,
Taichung Veterans General Hospital, Taichung, Taiwan, Taiwan; 7Master's
Program in Biomedical Informatics & Biomedical Engineering, Feng-Chia University,
Taichung, Taiwan, Taiwan
Dynamic contrast-enhanced MR (DCE-MRI) is able to distinguish malignancy from benign tissue by recognizing the differences in contrast enhancement that originates from their differences in microcirculation. DCE-MRI also evaluates some of the functional images, such as tissue perfusion and permeability of tumor vessels. Therefore, this ability can be used as a functional image to monitor the pathophysiological responsiveness to treatment. In this work, two-compartment model proposed by Buckley et al. was applied in DCE-MRI to monitor the sequential chemotherapy response of patient with LABC. We aim to find the perfusion parameters which are sensitive to chemotherapy response.