Kenneth K. Kwong1, Ona Wu1, Suk-Tak Chan1, Koen Nelissen1, David A. Chesler1
1Athinoula A. Martinos
Center for Biomedical Imaging,
In MR perfusion analysis, the tissue mean transit time τ is normally estimated indirectly by using the ratio of regional cerebral blood volume (rCBV) and regional cerebral blood flow (rCBF). We propose two different methods to estimate τ directly using signals from the tissue contrast agent bolus concentration time course.