Yanming Yu1, Quan Jiang2, Haoyu Wang3, Shanglian Bao3, E. Mark Haacke4, Jiani Hu4
1Logging Technique Research Iinstitute, great wall drilling company, China National Petroleum Corporat, Beijing, China, People's Republic of; 2Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI, United States; 3Beijing Key Lab of Medical Physics & Engineering, Peking University, Beijing, China, People's Republic of; 4Department of Radiology, Wayne State University, Detroit, MI, United States
The purpose of this project is to investigate the effect of T2* on permeability and effect of T1 on perfusion using a new pharmacokinetic model with simultaneously acquired T1 and T2* DCE-MRI data. The preliminary results demonstrate that 1) T2* has great effects on the estimation of permeability parameters; 2) T1 has great effects on the estimation of perfusion parameters; 3) both the T1 and T2* effects are much greater in tumors when compared to healthy brain tissue. In conclusion, simultaneously acquired T1- and T2*-weighted DCE-MRI data can be used to improve the estimation accuracy of permeability and perfusion parameters.