Ji Young Yoo1, Amy Haseley1, Anna Bratasz2, E. Antonio Chiocca1, J. Y. Zhang2, Donna Cain1, Kimerly Powell2, Balveen Kaur1
1Department of Neurological Surgery, OSU, Columbus, OH, United States; 2Department of Biomedical Informatics, OSU, Columbus, OH, United States
A novel oncolytic virus - 34.5ENVE enhanced by nestin and Vasculostatin expression has been described. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) revealed that mice treated with 34.5ENVE showed distinct spatial and temporal changes in the pattern of vascular leakage. Treatment of mice bearing subcutaneous and intracranial glioma with 34.5ENVE showed a significant increase in survival rate by 100% and 75% (respectively). This virus showed anti-glioma specific and anti-angiogenic effects. These preclinical results will facilitate future clinical testing of 34.5ENVE.