Lesley M. Foley1, Mioara D. Manole2,3, T Kevin Hitchens1,4, Chien Ho1,4, Henry L. Alexander2, Patrick M. Kochanek2,5, Robert S. Clark2,3
1Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA, United States; 2Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; 3Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States; 4Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, United States; 5Departments of Critical Care Medicine, Pediatrics & Anesthesiology, University of Pittsburgh, Pittsburgh, PA, United States
The aim of this study was to determine if CBF and PbtO2 disturbances seen immediately after pediatric asphyxial cardiac arrest (CA) persist 24 h after resuscitation. Hyperemia is still present in the thalamus whereas CBF values for all other brain regions return to sham values. Tissue oxygenation decreases to below acceptable thresholds in the cortex and thalamus when FIO2 is lowered to 0.21. Monitoring tissue O2 may be warranted to guide therapy following pediatric asphyxial CA.