Wouter M. Teeuwisse1, Aart J. Nederveen2,3,
Eidrees Ghariq1, Dennis F. Heijtel2,3, Matthias J. P.
van Osch1
1Radiology, C.J. Gorter
Center for High Field MRI, Leiden University Medical Center, Leiden,
Netherlands; 2Radiology, Amsterdam Medical Center, Amsterdam,
Netherlands; 3Spinoza Center, Amsterdam, Netherlands
Information on the dynamics of labeled spins is essential in ASL to enable absolute quantification and interpretation of the data. In this study multi-echo, multi-delay-time imaging is employed to study differences in spin dynamics of pseudo-CASL (PCASL) and velocity selective ASL (VSASL) and to study the influence of vascular crushing. It is shown that vascular crushing decreases the contribution of arterial signal in PCASL and both arterial and venous signal in VSASL. Delay times larger than 1800 ms or vascular crushing is needed to achieve sensitivity towards perfusion signal.