Qiang Shen1,2, Shiliang Huang1, Fang Du1, Timothy Q. Duong1,2
Institute, University of
The identification of ischemic penumbra and the distinction of this potentially reversible condition from irreversibly damaged tissue is of utmost importance for the initiation of treatment strategies. Although diffusion/perfusion MRI mismatch has been used to be an estimation of penumbra, it has been demonstrated overestimate penumbra. In this study, T2* weighted fMRI responses of stroke rats to oxygen challenge (OC) were investigated. DWI/PWI mismatch region showed significant higher than normal T2* weight signal increase. Tissues with higher than normal T2* weighted signal increase during OC and spatially around the ischemic core could be a better estimation of penumbra.