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Abstract #2172

Diffusion Tensor Parameters of the Optic Radiations Are Associated with Visual Acuity & Retinal Nerve Fiber Layer Loss Following Optic Neuritis

Robert a Bermel1, Salim E. Abboud1, Blessy Mathew2, Ken E. Sakaie2, Stephen E. Jones2, Michael D. Phillips2, Mark J. Lowe2

1Neurological Institute, Cleveland Clinic, Cleveland, OH, United States; 2Imaging Institute, Cleveland Clinic, Cleveland, OH, United States


Transsynaptic degeneration may occur in response to demyelinating disease, and may represent a future therapeutic target for neuroprotection in MS. We use optic neuritis as a model system to identify transsynaptic changes in the visual pathways, using multimodal imaging.