Mohit Saxena1, S. Senthil Kumaran2, Vinay Goyal1, Madhuri Behari1
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India; 2Department of N.M.R, All India Institute of Medical Sciences, New Delhi, India
Parkinsons disease is characterized by motor dysfunction. In this functional MRI study, we attempt to study the BOLD activation pattern with respect to the progression of the disease and the dopamine therapy. The enhanced activation of primary motor cortex in PD in the off state could be normalized to an extent by dopaminergic therapy. Compensatory mechanisms involving cerebellum and areas other than sensorimotor cortex are observed with the progression of the disease.